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KMID : 0363819670010010079
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Korean Journal of Nuclear Medicine
1967 Volume.1 No. 1 p.79 ~ p.82
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Further Evaluation of Androgen Therapy in Aplastic Anemia
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Abstract
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Patients with aplastic anemia were treated with a combination of depo-testosterone cyclopentylpropionate (Upjohn) and dexamethasone. In 7 of 15 patients treated, there was response in which either a significant increase in hemoglobin concentration, a prolonged interval or a cessation of blood transfusion requirement developed during androgen therapy. Younger patients with cellular marrow appeared to be better responding to androgen.
EEI (Effective Erythropoietic Index) formulated by Gardner & Nathan (1966)´ which was a helpful measurement as to whether patients with myelofibrosis whould respond to androgen, was evaluated in patients with aplastic anemia. It was concluded that EEI as well as ferrokinetics indices (Plasma-59Fe-disappearance rate, RBC "Fe net incorporation) did not significantly correlate with the degree of response to androgen in aplastic anemia.
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